Gajanan V. Korpe

Several per-O-acetyl and per-O-benzoyl glycosylbis-thiocarbamides were synthesized by the interaction of glycosylisothiocyanates and o-phenylenediamine. The identities of these newly synthesized compounds were established on the basis of usual chemical transformations, IR, 1H NMR, 13C NMR and Mass spectral studies. All the synthesized compounds have been evaluated for their antibacterial and antifungal activity against different bacteria and fungi by agar diffusion method.

Formamidines, Thiazoles, dithiazolidines, thiadiazines and other ring system derivatives have a long history of applications in pharmaceutical and agrochemical industries. Our interest in the chemistry of the formamidine  nucleus and its derivatives prompted us to explore the synthesis of 1-hepta-O-acetyl- β-D-lactopyranosyl-3-H/Aryl formamidines, N-hepta-O-acetyl- β-D-lactopyranosyl-N’-benzothiozolyl formamidines and N-hepta-O-acetyl-β-D–lactopyranosyl formimidic acid alkyl esters by reductive desulphurization of 1-hepta-O-acetyl- β-D–lactopyranosyl–H / aryl thiocarbamides, 1-hepta-O-acetyl-β-D-lactopyranosyl-3-[2-N-substituted benzothiazolyl] thiocarbamides and 1-hepta-O-acetyl-β-D–lactopyranosyl-O-alkyl thiocarbamates respectively using Raney Nickel. The identities of these newly synthesized derivatives have been established on the basis of chemical transformations and IR, 1H NMR and Mass spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram negative microorganisms. These compounds show most promising activity towards these micro-organisms.

Several 1-Tetra-O-acetyl-β-D-glucopyranosyl-5-aryl-isothiobiurets were synthesized by the interaction of tetra-O-acetyl-β-D-glucopyranosylthiocarbamides with various aryl isocyanatesand were evaluated for their antibacterial and antifungal activities. The identities of these new N-glucosides have been established on the basis of elemental analysis, IR, 1HNMR, 13CNMR and MS spectral studies.