Devanna N

The objective of the present work was to make different crystal forms of Amlodipine besylate. It was planned to prepare crystal forms using solvents of varying polarity and by change of phase and it was extended to characterize the prepared crystal forms using techniques like Scanning electron microscopy, IR spectroscopy, and Differential scanning calorimetry and/or X-ray diffractometry. Based on above these studies Amlodipine besylate pure was exisisted as Amlo-I, Amlo-II, Amlo –III and Amlo-IV forms were different in size and shape.

A simple, accurate, precise and reproducible method has been developed for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in combined tablet dosage forms. As there are no reported UV methods for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in their combined dosage form, a need was felt to develop new methods to analyze the drugs simultaneously. The estimation was done by multi-wavelength technique, at wavelengths of 217 nm and 234 nm over the concentration ranges of 0.7µg/ml and 7 µg/ml with mean recovery 100% for both drugs Vildagliptin and Metformin hydrochloride respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guide lines. Thus the proposed method can be successfully applied for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in routine analysis work.