Danole AB

Melt granulation has gathered increasing interest in the pharmaceutical industry for the concept of utilizing a molten liquid as a binder. Melt granulation process is currently applied in the pharmaceuticals for the manufacture of variety of dosage forms and formulation such as immediate release and sustained release pellets, granules and tablets. This technique has been used for improving bioavailability of poorly water soluble drugs. The review article gives updates about the latest developments in technology behind use of melt granulation process. Article deals with in depth basic information about granule growth mechanisms during melt granulation. The article also provides an insight to Equipments and factors influencing the melt granulation process & its applications to improve the dosage form characteristics which are utilized for industrial production.

In the recent years the pulsatile drug release systems are gaining growing interest. The pulsatile drug release where the drug is rapidly released after the well defined lag-time could be advantageous for many drugs or therapies. The sustained & controlled release devices are not applicable in some of the cases like the time-programmed administration of the hormones & many drugs. The living systems are the predictable dynamic resonating systems which require different amounts of drug at the expected times within the circadian cycle. The pulsatile drug delivery system has fulfilled this requirement. This system is such a system where the drug is released suddenly after the well-defined lag time or the time gap according to the circadian rhythm of the disease states. No drug is released from the device within this lag time. This method is good for the drugs with the extensive first pass metabolism & targeted to the specific site in the intestinal tract. The current article focuses on the necessities of pdds, diseases requiring PDDS, classification of pulsatile drug delivery system, current situation and future scope& marketed technologies of pulsatile drug delivery system.