D.T.Tayade

“Non-conventional” synthetic method has shown broad applications as a very efficient way to accelerate the course of many organic reactions, producing high yields, higher selectivity and lower quantities of side products consequently easier work-up and purification of the products.  One-pot two-component condensation of 1-formamidino-5-ethylformamidonothicarbamide (llla) with various isocyano-dichlorides(Xla-g) were carried out in presence of lemon juice as a biocatalyst respectively to synthesize a novel series of 2-substitutedimino-4-amino-6-ethylformamidino-1,3,5-thiadiazines (Xlla-g) which are neither to unknown. The structures were confirmed by conventional chemical characterization, elemental analysis and spectral studies.  

The solution studies the proton – ligand stability constant pK and metal ligand stability constants logk of binary (1:1) complexes of Cu(II), Co(II), Cd(II) and Ni(II)  with substituted thiocarbamido phenols have been studied at 0.1 M ionic strength in  70% ethanol-water mixture by Bjerrum method as adopted by Calvin and Wilson. It is observed that Cu(II), Co(II), Cd(II) and Ni(II) metal ions form 1:1 and 1:2 complexes with ligands (L1 & L3). The information acquired was used to estimate and compare the values of proton –ligand stability constant (pK) and metal-ligand stability constants (logk). The effects of substituents were studied from the evaluated information (pK and logk).

“Non-conventional” synthetic method has shown broad applications as a very efficient way to accelerate the course of many organic reactions, producing high yields, higher selectivity and lower quantities of side products consequently easier work-up and purification of the products.  One-pot two-component condensation of 1-formamidino-5-ethylformamidonothicarbamide (llla) with various isocyano-dichlorides (Xla-g) were carried out in presence of lemon juice as a biocatalyst respectively to synthesize a novel series of 2-substitutedimino-4-amino-6-ethylformamidino-1,3,5-thiadiazines (Xlla-g) which are either to unknown. The structures were confirmed by conventional chemical characterization, elemental analysis and spectral studies.  

Synthesis of 2-substitutedthiocarbamidophenols (III) was carried out by an interactions of 2-aminophenol (I) with various isothiocynates (II) by solvent free green synthetic non-conventional method as well as usual conventional method. Determination and justification of structure of products was established by usual chemical characteristics, elemental analysis and spectral studies.