Ch. Sai Akshitha

BioMEM’s are the biologically oriented MicroElectro Mechanical systems which are currently giving good market in the medical field and also attracting many researches for its development. These devices are defined as “devices or systems, constructed using techniques inspired from micro scale and nanoscale fabrication that are mainly for processing, delivery, analysis of biological and chemical entities. These BioMEM’s are having advantages over disadvantages. BioMEM’s are capable of analyzing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid cells and viruses. And there is currently  a large amount of BioMems work in the arena of drug delivery systems using micro fabrication technique. BioMems are under research in the field of drug delivery which helps in the future for the many dreadful diseases.  This review mainly gives an information about the different applications of BioMEM’s in the medical field.

Nanoparticles are submicron nano sized particles having the size range of about 1-100nm range. Because of their sub-microscopic size, they have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas, including medicine, engineering, catalysis, and environmental remediation. Escitalopram (ETP), an SSRI (selective serotonin reuptake inhibitor), and s-enantiomer of citalopram is exclusively used as an antidepressant. The drug shows extensive hepatic metabolism, reduced drug efficacy and potential side effects, which reduces its therapeutic index. So, the present study is focused on increasing the solubility and thus the bioavailability. The nanoparticles were prepared by using hot homogenization method by using Cutina as lipid, soya lecithin as lipophilic surfactant and PEG as hydrophilic surfactant. The prepared solid lipid Nanoparticles were evaluated for Drug content, entrapment efficiency and dissolution studies and stability studies and found that the Drug content ( 90.7%), Entrapment efficiency (  86.1 %) and Drug release of  ( 82.4%), Particle size( 796nm) and Zeta potential ( -29.4mV)