Bhartendu Sharma

Insulin remains indispensable in the management of diabetes mellitus since its discovery in 1921. Relatively, a large percentage of world population is affected by diabetes mellitus. In today's era; insulin delivery by alternative route is an area of current interest in the design of drug delivery system. Most of the global pharmaceutical companies are showing encouraging progress in their attempts to develop alternative insulin delivery technologies. For most patients with type 1 diabetes, the tedious part of the treatment is to tolerate needle after needle, both for glucose measurement and to deliver insulin. The introduction of insulin therapy years ago has saved the lives of millions of patients with diabetes. It is growing increase in the percentage of population having diabetes mellitus due to hereditary and environmental factor.  Needle-free insulin delivery appeared to be astonishing approach and its allure rested in being comfortable and safe. The document present here encompass, in brief, the emerging technologies and discoveries that are in pipeline, including insulin inhalers, implantable insulin pumps, insulin spray, smart cells, insulin pill, insulin complement, islet cell transplant, insulin nano pump and the other promising advances in safe and comfortable insulin delivery. Therefore it will be a tripartite task for the researcher, health authorities and community pharmacist to foster the long term safety profile and to provide comfortable insulin delivery.