Bapu R. Chavan

Parenteral delivery provides rapid onset even for the drug with narrow therapeutic window, but to maintain the systemic drug level repeated installation are required which cause the discomfort. Therefore, a delivery system that combines the simplicity and reliability of solid implant devices along with convenience and ease of administration on of micro-particles are desired. In situ gel forming system represents a desired alternate. The atrigel system is a proprietary delivery system that can be used for both parenteral and site specific drug delivery. it consist of biodegradable polymers dissolved in a biocompatible carriers when the liquid polymer system is placed in the body using standard needles and syringes, it solidifies upon contact with aqueous body fluids to form a solid implant. There are some advantages of these system are compatibility with a broad range of pharmaceutical compound, less invasive technique, direct delivery to a target area, protection of drug, sustained drug release, few type of atrigel are surgical implants, microspheres, liposomes and injectable gels.