B. Prakash Rao

This research aimed to evaluate a new approach for preparation of in situ gel and to design innovative peroral delivery systems for Ranitidine Hydrochloride (RHCl) able to enhance the control release. The present study was carried out to optimize and evaluate an oral in-situ gel containing ranitidine HCl with Pluronic F-127 and hydrophilic HPMC E50 by the simple mixing method. The compatibility of the polymers was proved by FTIR. The prepared in-situ gel formulations were tested for their physicochemical characteristics such as clarity, gel strength, gelation temperature, drug content, sol-gel transition time and in vitro release studies of ranitidine HCl-loaded in-situ gel formulation in phosphate buffer (pH 1.2 and 7.4. ) were performed using a modified diffusion cell across dialysis membrane. The prepared formulations were clear and Gel strength ranges from 31±1.6 to 33±1.2. The drug content for the prepared formulations was 97.23% to 99.02%.Then the Drug release at 12 h is 98.25 and thus shown controlled release.

The Losartan Potassium buccal tablets have been developed as controlled drug delivery systems to improve the efficacy of Losartan Potassium through mucosal absorption, reduce dose frequency, toxicity, to improve bioavailability and patient compliance. Many processing variables can persuade the characteristics of the Losartan Potassium buccal tablets. The aim of the study was to study the effect of some selected process variables in the concentration of drug/locust bean gum, hydroxy propyl methyl cellulose K4M on the hardness, mucoadhesive strength and in-vitro release at different hours by applying central composite design, accounting the above independent variables. The central composite design with an R2 value of 0.9695, 0.9928, 0.5839, and 0.7556 has selected as a suitable model for further analysis. The model F value of 44.52, 277.61, 7.02, 15.46 with probability P>F

Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, widely effective in the treatment of ophthalmic disorders like, corneal ulcers and conjunctivitis. In the present study, an attempt has been made to formulate ciprofloxacin hydrochloride as sustained release in situ gel systems utilizing the concept of ion- activated gelation using Gelrite alone and with sodium alginate in combination with HPMC E50 LV. Prepared formulations were evaluated for several parameters like drug polymer compatibility, viscosity, gelling and gel retention time, clarity, pH, drug content, antimicrobial efficacy, sterility and in vitro drug release. Among all the formulations, batches G3 containing 0.6 %w/v of Gelrite, A6 and A7 containing 1% w/w of sodium alginate with 0.5 and 0.75 % w/v of HPMC E50LV respectively were selected based on their gelling properties. The drug release of A6 extended upto 7 h and that of G3 and A7 extended upto 8 h. The formulations showed pseudo plastic behaviour after gelling. G3 showed better stability and clarity than the alginate formulations and was taken for further evaluations. It showed better antimicrobial efficacy when compared with standard. The mechanism of drug release from the best formulation was further evaluated. Hence the developed in situ system may be an alternative to conventional eye drops.