Ayyanki Anisha

End-stage renal disease patients have a higher prevalence of diabetes mellitus, hypertension, congestive heart failure and advanced age, along with an increased incidence of non-valvular atrial fibrillation, thereby increasing the risk for cerebrovascular accidents. The most frequent arrhythmia treated is atrial fibrillation, which necessitates the use of novel oral anticoagulants that have been approved to reduce the risk of thromboembolism and stroke. So, compared to traditional anticoagulants, apixaban was associated with a significantly lower risk of stroke or systemic embolism (2).Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease. On the other hand, DOACs are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close international normalized ratio monitoring (1). Several studies have investigated the safety and efficacy of apixaban in patients with ESRD and NVAF. The goal of this study is to determine the patterns of apixaban use and its associated outcomes in dialysis-dependent patients with ESKD and AF (3). This article gives an overview of clinical presentations, diagnostic procedures, complications and management of end stage renal disease.

Orthopedic is a branch of medicine dealing with the correction of deformities of bones or muscles. This research study aims to investigate the Health-Related Quality of Life (HRQOL) of Post-operative orthopedic patients and explore the factors that influence their HRQOL using WHO-BREF questionnaire, and by supplement counselling to address patient’s psychosocial needs and enhance their HRQOL. This study involved a sample of orthopedic patients who undergone various surgical procedures and were recruited from tertiary care hospital. The data was collected through interviews using WHO-BREF Questionnaire and analyzed using appropriate Statistical techniques. The findings contribute to a comprehensive understanding of the factors influencing the HRQOL of post-operative orthopedic patients, thereby highlighting the importance of incorporating counseling as a supportive measure in their care. Ultimately leading to enhanced patient outcomes and overall satisfaction. The P-value was found to be appropriate.