Ayesha Siddiqua

The aim of the present study is to enhance solubility of simvastatin by solid dispersion technique. Solid dispersions were prepared by fusion method by using various polymers. Formulation is optimized on the basis of acceptable solid dispersion properties and in-vitro release. In order to obtained best optimized product, 5 different formulations were developed. Different polymers like PEG 6000, HPMC 6000,HPC 1000 were taken as variables. Angle of repose, carr’s index, particle size, drug content and dissolution study were studied as response variables. The different physical properties showed best comparable results with drug. But higher percentage of drug release was observed when the formulation contained PEG6000 in 1:1.5 ratio (f5) compared to other formulations. Form this study it concluded that formulation (f5) which contained PEG (1:1.5) as polymer showed best dissolution profile compared to the drug. The formulation contained PEG 6000 was selected as optimized product.

Drug utilization review can be defined as review of drugs used in a population to determine effectiveness, potential dangers faced by the patients, problems arised due to drug interaction and also promotes rational use of drugs. Rational use of drugs minimizes polypharmacy , drug interactions minimizing the hospital stay. Our objective was to understand the pattern of occurrence of various cancerous disorders and promote rational use of drugs. It was a prospective observational study which was undertaken in Yashoda Cancer Institute, Hyderabad under the guidance of Dr. N. Bethune for a period of 6months. A total of 100 prescriptions were included in the study. The study criterion were the inpatients upto 90 yrs of age of either gender. Patient data relevant to the study was obtained from patient case records. According to the data collected we found that males (54%) predominated females (46%) and patients were more prominent in 41-60 age group. The use of anti cancer drugs in this hospital was found to be rational and more than 50% of the drugs prescribed are from National list of essential drugs. In conclusion, the use of anti cancer drugs was found to be rational. Pharmacist is the key person for better management of therapy based on stage and condition of patient and also manage the increased cost of therapy and increased risk of unwanted reactions. It has been our sincere effort to minimize the anticipated untoward events (atleast to some extent) by our dissertation

For patients suffering with different types of cardiovascular diseases, the need to understand the pattern of occurrence of the disease in a population is very essential. The goal of the present study was to understand the pattern of occurrence of the various cardiovascular diseases and bring awareness about the rational use of drugs. Total 100 patients suffering with different types of cardiovascular diseases were included in present study within a time period of 6months. It was a prospective randomized study. The tools which were used throughout the study were patient information sheets (case sheets) and questionnaire. As per the data collected from the case sheets of 100 patients it can be concluded that average prevalence of cardiovascular diseases were found to be more in males than in females. Among the various CVD high prevalence was found to be of hypertension. Common age group of CVD is observed as 40 to 60 years. We have concluded that the drugs used for the treatment of cardiac disease are almost found to be rational. Rational use of drugs minimizes poly-pharmacy, drug interactions and in turn it minimizes the hospital stay. The drugs prescribed are from national list of essential medicines. The prescribing habits, route of administration, dosage forms are found to be appropriate.