Asish Dev

Release of drugs via the skin has been always a challenging part for research due to obstacle properties shown by the outermost layer of skin stratum corneum. In the previous two decades, the transdermal drug delivery system has turn into a established technology that offers important clinical repayment over additional dosage forms. Because transdermal drug delivery offers controlled as well as programmed rate of release of the drug into the patient, it is capable to maintain steady state blood concentration. It’s a advantageous form of drug delivery because of the apparent advantages e.g. suitable and pain-free self-administration for patients, prevention of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs than other routes of deliverance.Thepresent article reviews the choice of drug candidates and polymers, advantages, disadvantages of formulation, design and the methods of evaluation, augmentation techniques based on drug/vehicle optimization such as selection of drug, prodrugs and ion pairs, supersaturated drug solutions, vesicles, liposomes, particles and complexations. This review also emphases on the recent innovations in TDDS, which be able to used for the research and improvement of pharmaceutical dosage form intended for transdermal drug delivery.

Efficient Helicobacter pylori elimination requires delivery of the antibiotic locally in the stomach. High dose of metronidazole (250 to 750 mg) is difficult to incorporate in floating tablets but can simply be given in liquid dosage form.  By keeping the above observation in mind, we made an attempt to build up a new raft forming oral in situ gelling system of metronidazole with improved residence time using sodium alginate as gelling polymer to eliminate H. pylori.  Methods: oral in situ gelling formulations were prepared using sodium alginate, xanthan gum, calcium carbonate, and sodium bicarbonate. Prepared formulations were evaluated for density, viscosity, floating lag time, floating duration, swelling index and in vitro drug release. Results. All formulations (F1–F12) showed floating within 180 s and had floating duration  of more than 24 h. every formulations showed excellent pourability. It was observed that concentration of sodium alginate and xanthan gum had major influence on floating lag time, cumulative percentage drug release and other evaluation parameters. The batch F11 was optimized since it have good pourability with extended release of 10 hrs. Conclusion: oral in situ gelling system of metronidazole  can be formulated by  use of sodium alginate as a gelling polymer and xanthan gum as release retardant to control  the drug release for more than  10 hrs.

The Mouth Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970’s and combats over the use of the conventional tablets, syrups, capsules which are the other oral drug delivery systems. Orally disintegrating dosage forms can address the pharmaceutical needs of the paediatric and geriatric patient group having difficulties in swallowing the conventional solid oral dosage forms. Orally disintegrating dosage forms also have the advantage of self medication, pain avoidance hence better patient compliance. Taste masking of bitter drugs is an important parameter. Orally disintegrating dosage forms may have an added advantage of bypassing first pass metabolism. Acyclovir is an antiviral drug used for the treatment of herpes simplex virus (HSV), mainly HSV-1 and HSV-2 and varicella zoster virus. It is a BCS class III drug. Hence an orally disintegrating tablet formulation of acyclovir was prepared by direct compression techniques after incorporating superdisintegrants croscarmellose sodium , sodium starch glycolate and Crossprovidone . Eight formulations were prepared. Tablet containing sodium starch glycolate and croscarmellose sodium showed excellent in vitro dispersion time and drug release as compared to other formulation. After   study of eight formulations F8 showed short dispersion time with maximum drug release in 25 min. It is concluded that fast disintegrating acyclovir tablets could be prepared by direct compression using superdisintegrants.