Ashwani Kumar

Phytochemical characterization of plants is an important task in medicinal botany and drug discovery. In the current study, Catharanthusroseus is considered as medicinal plants by evaluation of phytochemical composition. Methanolic extract of the leaves of C. roseus was prepared by soxhlet extraction. The extract was used to detect the presence of different phytochemicals like alkaloids, phenols, flavonoides, tannin, lignin, steroids, glycosides, saponins, terpenoides and anthraquinone by their biochemical tests. Alkaloids, tannin, steroids, glycosides were found to be present in methanolic extract of C.  roseus.

Over the years, different formulation technologies for gastroretentive dosage delivery were investigated and patented. Well-designed controlled drug delivery system can overcome the problems of conventional therapy and enhance the therapeutic efficacy of a drug. There are various approaches in delivering a therapeutic substance to target site in a sustained controlled release fashion. One such approach is using multiparticulate as carriers for drugs. Such systems have advantages over single-unit dosage forms as they avoid the all-or-none gastric emptying nature of single-unit systems. However, multiparticulate dosage forms are gaining favor because of potential benefits like predictable gastric emptying, no risk of dose dumping, flexible release patterns and increased bioavailability with less inter- and intra-subject variability. The purpose of writing this review on method of prepare floating multiparticulate is to compile the recent literature with special focus on the classification and formulation aspects, principal mechanism of floatation to achieve gastric retention, characterization of floating multiparticulate system. Keywords- multiparticulate system, design and method of preparation, floating microspheres, beads, granules.