Ashok Ahirwar

Liquisoild technique is a novel concept for delivery of drugs through oral route. This approach of delivering drugs is suitable mostly for lipophilic drugs and poorly or water insoluble drugs. With this approach sustained release formulation of hydrophilic drugs or freely water soluble drug can also be prepare. Release enhancement of poorly soluble drugs is achieved by choosing nonvolatile solvent with maximum drug solubility, Unlike this, in retardation of drug release nonvolatile solvent with lowest drug solubility is choosen. It was found from the study that if nonvolatile solvent alone is not sufficient for prolonging the drug release then various release retarding agent is used. The release retarding or sustained release agent used, may be of natural or synthetic origin.