Ashish Kumar Garg

The present research work was aimed to enhance the solubility and dissolution rate of Olanzapine using Poloxamer as carrier by preparing solid dispersion. The solid dispersions and physical mixtures prepared was also evaluated  for the drug content and percentage drug yield and characterization of prepared systems is done with the help of in-vitro drug release, FTIR, XRD and DSC analysis. The results obtained showed that the percentage yield and percentage drug content was 98.32% and 99% respectively. It was clear that there was no loss of drug and polymer. The rate of dissolution of the drug in the case of solid dispersions was much enhanced as compared to the pure drug and their physical mixtures. FTIR spectra showed that there was not any interaction or hydrogen bonding between the drug and polymers in solid dispersions as well as physical mixtures. The polymorphic changes were studied with the XRD gave the idea that the solid dispersions were quite amorphous in nature as compared to the pure drug. In the diffraction pattern for solid dispersions, the number of crystalline peaks due to drug had disappeared. DSC showed that there was shifting in melting endotherm of drug in case of solid dispersion. From the XRD and DSC it was confirmed that the increase in the solubility and dissolution rate was due to polymorphic transition of drug from crystalline to amorphous form.

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Pantoprazole sodium sesquihydrate as a model drug and to optimize its drug release profile. Pantoprazole sodium tablets were prepared by direct compression technique. Formulations contained Xanthan gum, PVP K30 and gas generating agent such as sodium bicarbonate and citric acid were taken as independent variables. The physical parameters of the tablets were characterized and were found within the limits. By comparing dissolution profiles of different formulations, the formulation F5 was considered as a better formulation. The drug release from all the formulations was found to follow zero order kinetics and Peppas modeling. The diffusion exponent of formulations was found (n

The present study aims at the formulation of a floating drug delivery system of an antiulcer drug nizatidine using different grades of HPMC (K100, K4M, K15M & K100M) and an effervescent agent i.e. sodium bicarbonate. It was found that the release rate of nizatidine from tablet formulations prepared from HPMC K100LV was very high as compared to that from formulations containing higher viscosity grades namely K4M, K15M and K100M. In the current study, it was also found that overall rate of drug release tends to decrease with increase in concentration of HPMC. These observations are in agreement with the results reported in literature i.e. with the increase in polymer concentration and viscosity grade, the viscosity of gel layer around the tablet also increases leading to enhanced diffusional path length for the drug to follow and thus limits the release of active ingredient.