Arijit Gandhi

Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids. These lipid nanoparticles modify drug release, body distribution and kinetics of associated drugs. solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations, production techniques, drug incorporation, loading capacity and drug release, characterization and applications. The potential of SLN to be exploited for the different administration routes is highlighted also. Key words:  Solid lipid nanoparticles , colloidal drug carriers, homogenization, Drug Targeting.

  Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. The structure of these materials has a great impact on their physical and chemical properties. As a result of their unique behaviour dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. The paper gives a concise review of dendrimers physico-chemical properties, types, synthetic pathway & their possible use in various aspects of research, technology and treatment of disease. Key words: Dendrimer, targeted drug delivery, gene delivery, dendrimer synthesis, dendrimer properties, dendrimer types.