Archana Shrivastav

Hospital acquired infections are commonly associated with Methicillin Resistant Staphylococcus aureus infection and treating these infections with chemotherapy is very perilous. The augment of multidrug-resistant strains makes it necessary to discover new classes of antimicrobials and compounds that restrain their resistance mechanisms. In the past few decades, the search for new anti-infective agents has betrothed many research groups in the field of ethno pharmacology. Many focus on determining the antimicrobial activity of plant extracts found in folk medicine, essential oils or isolated compounds. There are a large number of species that have been and are still used as medicinal plants, particularly in folk medicine. In the present study, we analyse the possibility of essential oils as potential antimicrobial crude drugs as well as a source for natural compounds that act as new anti-infectious agents.

  This study was conducted for qualitative estimation of serum proteins separated by SDS-PAGE in order to describe the definition of potential serum proteins that may act as diagnostic marker in oral cancer. Serum samples of 25 biopsy confirmed cases of oral cancer and normal controls of similar age group were subjected to SDS-PAGE on a 12% resolving gel, followed by staining with Coomassie Brilliant Blue R-250. Protein fractions were analyzed using computer software program “Gene Genius Gel Documentation and Analysis System”. Major protein fractions ranging in molecular weights from 1.46-159 kDa were observed. Raw volumes of most of the protein fractions seem to be increased in majority of oral cancer cases as compared to normal control. Protein fractions 56-58 kDa were undetected in normal controls under 80 years of age but appeared in 54% of Oral cancer patient. Further advancement of this work could yield better resolution of protein fraction 56-58 kDa that could serve as marker for oral cancer.