Anuj Kumar Sharma

Ulcer is lesion on skin or internal linings of organs or Gastro-intestinal tract, which leads to degradation of cells in the area of occurrence which may be followed by bleeding or cancer at later stages. Peptic Ulcer Disease known as Ulcus pepticum have mucosal erosions equal to or greater than 0.5 cm of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. The present study was to evaluate Anti-ulcer activity in Trichosanthes dioica (Roxb.) via experimental ulcer models in animals through Histopathology study of Rat’s stomach. The leaves of Trichosanthes dioica (Roxb.) were collected from farms in and around Hastinapur district. Around two kilograms of the leaves of plant shrub were collected and were kept in shade for the purpose of drying the leaves completely. Sprague-Dawley rats (150 – 200 g) were procured from the animal house of Subharti University (n=90). The three animal models were used for the present study, mainly, Pylorus ligation, Ethanol Induced and Indomethacin (NSAID’s) ulcer models. Five groups of Animals were made, with n=6 for each group. The histopathology study of rat’s stomach was carried out for each ulcer model, and during the examination of rat’s stomach, it was clearly shown, that Trichosanthes dioica has potent Anti-ulcer activity. The Research thus primarily focuses using the plant for further study and to bring an effective and efficient ulcer healing drug in the market.

Ulcer is tissue erosion, either on skin or inside the body, for e.g. lining of gastrointestinal tract. The diverse causes for ulcer development range from, Genetic factors to Physiological/ Environmental factors. Helicobacter pylori recently found to be responsible for majority of peptic ulcer cases. Peptic ulcer diseases are extremely common in developing and developed countries with annual incidence of 1 to 3 per 1000th of the population. PUD is an important cause of morbidity and health care costs; estimates of expenditures related to work loss, hospitalization, and outpatient care are $5.65 billion per year in US. It affects 1 in 10 men & 1 in 15 women in Europe. Due to side effects from conventional drug therapy and non-specificity of therapeutic choices, there is inclination towards Traditional medicines with low cost and low adverse effect incidences. Many photochemical substances have been found to be effective against pathogenic factors responsible for ulcer formation and its severity. Alkaloids, Flavonoids, Terpenoids, & Tannins have been researched to possess potent Gastroprotective activities. Glycosidal components have been found effective against Helicobacter pylori gram negative strains. Trichosanthes dioica (Roxb.) found in flora and fauna of Uttar Pradesh have high concentrations of terpenoids, flavonoids, cucurbitacins, which have been researched for having anti-inflammatory and wound healing activities. The present study clearly shows the effectiveness of Trichosanthes dioica (Roxb.) in having Gastroprotective activity. This gives clear indication that Trichosanthes dioica shall be researched upon to bring effective drug in market against ulcer diseases.