Anita Hosmani

A simple, precise and economical UV Spectrophotometric method has been developed for the estimation of Tolterodine tartarate in bulk and pharmaceutical dosage form. The method is based on measurement of absorption at maximum wavelength of 283.0 nm. Linearity for detector response was observed in the concentration range of 10-50 μg/ml. The accuracy of the method was assessed by recovery studies and was found to be 99.80%. The LOD and LOQ were found to be 0.1865 and 0.5621 respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision, specificity and robustness and ruggedness. The results were validated statistically as per ICH Q2 R1 guideline and were found to be satisfactory. The proposed method was successfully applied for the determination of Tolterodine tartarate in commercial pharmaceutical dosage form.