Anand P. Khadke

Cancer drug development is leading the way in exploiting molecular biological and genetic information to develop ’personalized’ medicine. The therapies such as immunotherapy, gene targeted nucleic acid therapy, targeting angiogensis for treatment, chemotherapy are introduced for the treatment of cancer. In chemotherapy the drug new drug are introduced nivolumab, bevacizumab, belinostat, bilinatumomab.

The novel compounds containing two phenyl rings at 3, 5 position of 1, 2-pyrazoline sulphonamide derivatives synthesized. N-((3-(4-aminophenyl)-5-(3,4-disubstitutedphenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine screened  for Angiotensin II receptor antagonistic activity  in  1K-1C goldblatt hypertensive rats using tail cuff method. N-((3-(4-aminophenyl)-5-(3,4-dichlorophenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine sulphonamide exhibited potent antihypertensive activity.