Amitabh kumar

To evaluate the anti-convulsion activity of Crocus sativus linn. aqueous extract  in electrical induced epilepsy models. To compare the anti convulsant activity of crocus sativus linn. with phenytion .After obtaining Institutional Ethical Committee approval, Wistar albino rats (150-200g) of either sex were randomly divided into 5 groups of 6 animals each. Dried powder of crocus sativus linn. was boiled with distilled water, cooled, filtered, placed on hotplate for complete evaporation, finally weighed and stored. The control group, test group and standard drugs group received saline, crocus sativus linn. extract (200,400 & 800 mg/kg), phenytoin (25 mg/kg) respectively by oral feeding. The anti-convulsent effect was assessed by maximal electrical shock (MES) in rats. In electrical induced epilepsy models It implies that saffron 400mg/kg (groupIV) and 800mg/kg(groupV) significantly (p