Design and In Vivo Evaluation of Solid Dispersions Using Manidipine

The study was aimed to formulate solid dispersions of Manidipine by using different novel carriers like Labrafac PG, Kolliwax RH 40, Soluplus, Kolliwax GMS II, Kolliphor EL and SLS in drug carrier ratio by using solvent evaporation method. The formulations were characterized for physical appearance, solubility and in vitro dissolution studies. The optimized formulation was characterized by, Formulation SD13 was found to be optimized one based on the solubility, dissolution and other parameters using Kolliwax GMS II and SLS.  The drug release of the optimized formulation was found to be 99.41±5.38% within 90min. Powder X-ray diffraction studies performed on solid dispersion showed that Manidipine existed in the amorphous form within the solid dispersion formulation fabricated using the solvent evaporation process. Additionally, scanning electron microscopy studies suggested the conversion of crystalline Manidipine to an amorphous form. Furthermore, the pharmacokinetic parameters of the optimized Manidipine solid dispersions showed increased AUC0–t, AUC0–∞ and Cmax by 2-folds. These results suggest that the preparation of Manidipine solid dispersions using the solvent evaporation technique without might be a promising approach for improving the oral bioavailability of Manidipine. Therefore, the solid dispersions using Kolliwax GMS II as hydrophilic carrier in the combination of SLS can be successfully used for improvement of solubility and bioavailability of Manidipine.