Synthesis and Antimicrobial Activity of Some Novel 1, 3,4-Thiadiazole derivatives.

The earlier sources of drugs were from plant, animal and mineral sources, but due to the lack of potential action and definitive cure and sometimes more toxicity, the discovery of new drugs that are more potential and less toxic is essential. The synthesis of derivatives has been an important part and is aimed at modifying the action of drugs, particularly to reduce the side effects and to potentiate the drug action. Today more than 60% drugs used in practice are synthesized derivatives and day-by-day the scope of synthetic medicinal chemistry is broadening. The substituted 1,3,4-thiadiazole moieties are already known for different biological activities. Here we have synthesized some novel 1,3,4-thiadiazole analogues combining with different substituted aromatic and aliphatic system with view to get a good antibacterial activity withless toxicity and side effects. All the synthesized compounds were screened for antibacterial activity. As expected 1,3,4thiadiazole derivatives exhibited significant and moderately antibacterial when compared with standard drugs. Therefore in search of new generation of the active compounds, it maybe worthwhile to explore the possibility in this area by introducing different Functional groups or by cyclization as substitutions which may result into better pharmacological agent.