Formulation and Evaluation of Topical Adapalene Emulgel

Topical drug delivery systems have been utilized for centuries for the treatment of local skin disorders. One side the topical applications of the drug provides the potential advantages of delivering drug straightly to the site of action and delivering drug for extended period of time at the effected site that mainly acts at the related regions. On the other hand, topical delivery system elevates the contact time and mean resident time of drug. The aim of the work is to develop & characterize adapalene emulgel formulation. Adapalene emulgel formulations were prepared by dispersing Carbopol 934 in distilled water with constant stirring at a moderate speed, then the pH was adjusted to 6 - 6.5 using Triethanolamine. Evaluation of the adapalene emulgel was carried out for Physical appearance, Rheological study, pH values, Spreadability, Drug content determination, In vitro release study, Accelerated stability studies. It was noticed that all formulations were liquefied and diluted at the end of the experiments, indicating water diffusion through the membrane. The accelerated stability studies were performed according to ICH guidelines for three months & emulgels were found to be stable in differing temperature. The results demonstrate that the release of the drug is dependent on viscosity of the polymer used.