Freeze Drying Method for Enhancement of Solubility and Dissolution Rate of Poorly Aqueous Soluble Drug Paliperidone In Vitro–Evaluation

The main objective of the study is to enhance the dissolution rate and solubility of paliperidone by using the solid dispersion technique which were wildly used in pharmaceutical company because of its less cost. Paliperidone is antipsychotic classes of drug that can be used for the treatment of schizophrenia. Initially preformulation studies were conducted to check the incompatibilities of drug substance. Initially phase solubility studies were performed with respect to different molar ratio. Drug polymer interactions were investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). As indicated from XRD and DSC data, paliperidone was in the amorphous form, which explains the better dissolution rate of then drug from its solid dispersion. Solid dispersion of paliperidone were prepared to check the solubility of paliperidone because of its poor solubility issue by using the different polymer and to find out the effect of various solubilizer on its solubility and dissolution rate.