Management of Cyclosporin -A Induced Gingival Overgrowth -A Case Report With Immunohistochemical Observations

Cyclosporin A (CsA) is a potent immunosuppressant acting mainly on T lymphocytes by blocking intracellular processes of T cell activation. Gingival overgrowth (GO) is a well-documented side effect associated with the systemic use of cyclosporin A, an immunosuppressive drug extensively used for the prevention of organ transplant rejection, as well as in the treatment of immuno-related disorders. It would appear from both human and animal models that plaque-induced inflammatory changes have a significant part in the pathogenesis of such a disease. Gingival overgrowth is a clinical condition that poses functional and aesthetic problems. This article describes a case of cyclosporin A induced gingival overgrowth and its management.