Studies of Drug-Polymer Interactions of Carvedilol with various Polymers using some Analytical Techniques

The present study aims at investigating the different combinations of polymers with inclusion complex of Carvedilol (CR)-Hydroxypropyl betacyclodextrin (HPβCD) prepared in a ratio of 1:1 by use of various analytical techniques like Fourier Transformation Infrared spectroscopy (FTIR), X-ray diffraction technique (XRD), Digital scanning calorimetry (DSC), Thermo gravimetric analysis (TGA) as a part of preformulation studies. Various polymers used for the present study were Sodium alginate (SA), Hydroxy propyl beta cyclodextrin (HPBCD), Hydroxy propyl methyl cellulose LV E-15(HPMC), Pectin (P), Eudragit NE30D (EU). This study indicated that Carvedilol formed inclusion complex with the HPβCD, but in combination with other polymers, drug did not show any other interactions.