Recent Advance of Ocular Drug Delivery System

Eye is the most exclusive organ of the body and various drug delivery systems are used to deliver drug into eye. Eye diseases are commonly encountered in day to day life, which are cured or prevented through the conventionally used dosage forms like eye drops, ointments. Delivery to the internal parts of the eye still remains troublesome due to the anatomical and protective structure of the eye. To improve ocular drug contact time, bioavailability and residence time, and to reduce the patient discomfort, frequency of dose, as well as to slow down the elimination of the drug there are significant efforts concentrating towards newer drug delivery systems for ophthalmic administration. This review focuses on the various new drug delivery systems applied in eye like inserts, in-situ gel, the newly developed particulate and vesicular systems like liposomes, pharmacosomes and discomes, niosomes, nanoparticles, iontophorosis, corneal shields, drug embedded contact lenses, ocular wafers etc  and the most recent advanced approaches of the ocular delivery systems like the delivery of the genes and proteins to the internal structures which were used in treating the diseases caused due to genetic mutation, along with safety evaluation of ocular drug delivery formulations with some case studies.