Synthesis of Some Novel Triazole Heterocyclic Derivatives as Antibacterial Agents

4-(4′-chlorophenyl)-thiazol-2-carbohydrazide(2) obtained from Ethyl-4-(4′-chloro phenyl)-thiazol-2-carboxylate(1) by the treatment with hydrazine hydrate. The synthesis of Potassium-[4-(4′-chlorophenyl)-thiazol]-2-dithiocarbazinate(3) was performed from reaction of 2 with alcoholic potassium hydroxide and carbon disulphide. Moreover 4-amino-5-(4′-(4′′-chlorophenyl)thiazol-2′-yl)-3-mercapto-4H-1,2,4-triazole(4) were obtained by refluxed in the presence of compound 3 and hydrazine hydrate with water. The condensation of 4 with substituted aromatic aldehydes generated the corresponding different triazole Derivatives (5a-m). The structures of the compounds were confirmed by elemental analysis and spectral analysis. Antibacterial activity of the synthesized compounds was evaluated by tube dilution method against two gram positive and two gram negative bacteria using ciprofloxacin as standard.