Time-of-flight Techniques role in the survival Breast Cancer using Hybrid PET/CT Imaging

Positron emission computed tomography (PET) has significant role in oncology field. Commonly used in the purpose of evaluation and management including tumor diagnosis, staging, restaging and monitoring patient response after therapy.  It has the ability in the evaluation and detection of the metabolic activity in targeted tissue inside human body. This often achieved by using radiopharmaceutical 18F-Fluorodeoxyglucose (FDG).The annihilation reaction occurred between both electron and positron which end up with 511 keV pair photons emitted and recorded using special conventional block detectors based on Lu2SiO5:Ce (LSO) and Bi4Ge3O12 (BGO) scintillators which has a special characteristics in terms of crystal absorption efficiency, density, light yield , spatial and time resolution. The aim of this study is to identify the effects of time of flight (ToF) and partial volume effect (PVE) as quantitative imaging parameters in the early detection of breast cancer in Eastern province using 18-FDG as metabolic imaging radiotracer and PET/CT mCT flow Scanner. A literature review was conducted to understand the role of image processing parameters in the oncology imaging cases specially breast cancer using PET/CT machines. Publish med, Google Scholar and Nuclear medicine Journal were the research original source.