Formulation and Evaluation of Sustained Release Mucoadhesive Microspheres of Metformin Hydrochloride

Mucoadhesive microspheres of metformin hydrochloride (HCL) were successfully developed by emulsification /evaporation techniques to achieve the optimum effect for prolong duration of time. All the prepared formulation was subjected to different type of evaluation like, practical yield, particle size, entrapment efficiency, in vitro release study, in-vitro kinetic study and percentage of mucoadhesion. Particle size was determined by image microscope and the average particle size of prepared formulation was found in the range of 90.32±1.8  to 154.55±0.20 μm for all batches .Cumulative percent drug release was found to be maximum for F4 and F9 (90.88±0.59 and92.10±0.414). Formulation F1,F2,F3,F4,F5,F7,F9 show Zero order releases profile and other formulations like, F6 show Hixon, F8 show Higuchi , F 10 show First order kinetic. All the batches showed good in vitro mucoadhesive property. It was also found that the prepared formulations not showing any interaction .The satisfactory result of different evaluatory parameters, reflect that the experimental study will prove to be a effective delivery system.