UV–SPECTROMETRIC DETERMINATION OF SORAFENIB TOSYLATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

  A new, simple, economic and sensitive UV-spectrophotometric method was developed for the determination of Sorafenib in bulk and pharmaceutical formulations. The developed spectrometric method was validated for selectivity, linearity, range, precision, accuracy, ruggedness and sensitivity. The method has demonstrated excellent linearity over the range of 2-10 μg/ml with regression equation: y=0.079x-0.0081 and regression correlation coefficient r2=0.999. The developed method demonstrated consistent high recoveries (97–99%) and low relative standard deviation (< 5%) at 265 nm. Moreover, the method was found to be highly sensitive with low limit of detection (0.028 μg/ml) and limit of quantitation (0.085 μg/ml). The apparent molar absorptivity and Sandell's sensitivity was found to be 48.09 mol-1cm-1 and 0.013245 µg/cm2, respectively. The validated method was successfully employed for the drug content analysis from tablet preparations. Additionally, the method was also employed for pH metric solubility analysis of the drug.