ANTIHYPERTENSIVE BIOADHESIVE DRUG DELIVERY SYSTEM USING COMBINATION OF STARCH WITH POLYMERS

  Mucoadhesive delivery systems were proven to be suitable for the purpose of reduction of transit time of the dosage form through the gastro-intestinal tract, and increasing bioavailability of drug. Buccal tablets of Carvedilol were prepared by direct compression method for using various compositions of combination of Starch: C934 and Starch: HPMCK15M in various ratios. The tablets were evaluated for their characteristics properties, mucoadhesion and in vitro-in-vivo study. All the physicochemical properties were acceptable within the limit. Formulation containing starch and Carbopol 934(E4) showed better bioavailability as compared to tablet containing  Starch and HPMCK15 (F5) and The bioadhesive strength of the formulations containing polymers were in the order of E4> F5. Stability studies were carried out as per ICH guidelines and formulations were found to be Stable.