Evaluation of Anti--Cholesterolemic activity of Ayur-ns-01 in high Cholesterol Diet Induced Hypercholesterolemia in rats.

Hyper-cholesterolaemia is one of the leading causes of the major diseases like angina pectoris, myocardial infarction, atherosclerosis which increases the mortality rate every year. This study includes the evaluation of sample Ayur NS01 for anti-cholesterolemic effect using two models HCD induced hypercholesterolemia and lipid emulsion tolerance test (LETT) in rats.  The evaluation was made in different doses (1.35gm/kg, 1.8gm/kg,2.25gm/kg ) of Ayur NS01 sample. The lipid profile parameters like LDL, total cholesterol, VLDL and lipid emulsion tolerance were studied in the normal, high cholesterol diet induced hypercholesterolemic , AyurNS01 and  the standard drug atorvastatin (10mg/kg) administered rats. The results of HCD alone administered rats (group II) were compared with normal rats. The results obtained in the HCD and various doses of rats of AyurNS01, atorvastatin were compared with HCD alone administered hypercholesterolemic rats. From the results of first model of this study it is confirmed that the sample of AYUR NS01 has shown a significant reduction in the total cholesterol, triglycerides, LDL levels when it is compared to the HCD induced hypercholesterolemia rats. From the results of Lipid emulsion tolerance test, it is also confirmed that the sample of has also shown a reduction in the serum triglyceride levels in the AYUR NS01 treated groups as compared to the control rats treated with lipid emulsion. Keywords- Hyper-cholesterolemia, high cholesterol diet, lipid emulsion, Ayur NS-01