Development of Matrix Tablet of Aceclofenac with Chitosan and Hydroxypropyl Methyl Cellulose (HPMC) As Co-Polymer.

Chitosan, a linear binary heteropolysaccharide, composed of β-1, 4-linked glucosamine (GlcN) with various degrees of N-acetylation of GlcN residues. It is a non-toxic, biocompatible and biodegradable natural polymer of high molecular weight (~500,000 kDa). The degree of deacetylation (DD) and molecular weight (MW) are two fundamental parameters that can affect the properties and functionality of chitosan. HPMC is the dominant hydrophilic vehicle used for the preparation of oral controlled drug delivery systems. Hydrophilic polymers are widely used in controlled release systems due to their favorable functionality. Enhancing the mobility of the polymer chains and diffusing of the drug out from such polymer matrices could be done by inclusion of different types of excipients at different concentrations. The present manuscript describes the attempt undertaken to develop the matrix tablet of Aceclofenac along with different grades of chitosan and HPMC as a copolymer & to study effect of it on the swelling behavior and the drug release pattern.