Applications of Liquisolid Technique for Different Water Insoluble Drugs: A Review

In the last decade, poorly soluble drugs have been an area of concern for all the researchers in the field of pharmacy. A number of researches have been carried out to enhance the solubility and dissolution properties of such drugs. This study deals with a comprehensive review of liquisolid technique carried out mainly for biopharmaceutical classification system (BCS) class II & IV drugs. These drugs are having problems of poor solubility, dissolution and thus poor bioavailability. Various studies conducted on a number of drugs so far, have been reviewed. A variety of techniques such as micronization, salt formation, complexation, solid solutions, and liquisolid technique etc. have been used to overcome such problems. It has been observed that liquisolid technique is the most promising way for solubility and dissolution enhancement of such drugs. It can be concluded that liquisolid technique results in increased solubility, dissolution and thus bioavailability.