The Non-Aqueous Potentiometric Determination of Pharmaceutically Potent Drug Aspirin

The non-aqueous potentiometric determination of pharmaceutically potent drug aspirin by using isopropyl alcohol as the solvent and alcoholic KOH as the titrant has been carried out. The effect of solvent and concentration on potentiometric determination of aspirin has been studied followed by the estimation of aspirin in single component tablets. The titrations were carried out using glass and calomel electrode pair. The method was found to be convenient for assay of aspirin and results obtained are comparable with those obtained by IP method. Solvent isopropyl alcohol gives much more accurate result as compare to other solvents with minimum % error. In study of effect of concentration, the results obtained are more accurate with positive errors at low concentration whereas, negative errors at high concentration. The error is just +0.11% when 1.804 mg of aspirin was titrated. Confidence level of weight titrated and weight found in respect of aspirin is 0.46 which is statistically non significant.