A Basic Approach on Sustained Release Drug Delivery System

The oral route of administration is considered as the most widely accepted route because of its convenience of self administration, compactness and easy manufacturing, in which the sustain release drug delivery replaces the conventional administration of drug by delivery system. Recently, greater emphasis has been placed on controlling the rate and or site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficacy, solving problems concerning targeting of a drug to a specific organ or a tissue and controlling the rate of a drug delivery to the target site. Matrix system are favored because of they are easy to formulate, and showing better patient compliance, effective etc, than ancient drug delivery, which showing many drawbacks like repeated administration, fluctuation in drug plasma level etc.; developing oral sustained release matrix tablet with constant release rate has always being beneficial to the pharmaceutical technologist. Matrix type drug delivery systems are an interesting and promising way for developing an oral controlled release system, which will maximize the pharmacological benefits and minimize the potential side effects. The matrix tablet releases the drug in continuous manner like diffusion and dissolution controlled way. Hydrophilic polymers with high gelling capacity are of particular interest in the field of matrix tablet. Key words: Sustained release, Oral formulations, Hydrophilic polymers, Matrix tablet.