Formulation, Evaluation and Comparison of Sustained Release Matrix Tablet of Losartan Potassium Using Natural Polymers

The aim of this research work was to Evaluation of Some Natural Polymer used as Sustained Release Matrix Tablet, any pharmaceutical formulation contains two ingredients one is the active ingredient and other is an excipients. An excipients help in the manufacturing of dosage form and it also improves physicochemical parameters of the dosage form. Polymers play an important role as excipients in any dosage form. They influence drug release and should be compatible, non-toxic, stable, economic etc. and develop a fixed Dose Combination product in a two different strength using same blend for both the strengths of tablet as a SR tablet formulation. In the tablet, Extended Release layer consist of Antihypertensive Drug belonging to class β-selective adrenergic blocking agent without partial agonist or membrane stabilizing properties. Extended release preparation provides sustained release and reduces the chances of tough related side effects. In selected cases of extended release preparation of this drug used in treatment of hypertension and congestive heart failure. The clinical studies have shown beneficial role of this drug as an extended release preparation. The main objective of the present study was to develop, formulate and evaluate a matrix tablet by using hydrophilic natural retardant polymers which would retard drug release in upper GI tract and should start releasing the drug when it reaches the alkaline environment of small intestine. Okara and Tramarind Gum Mucilage were investigated as the model hydrophilic retardant polymers. Wet granulation method was and nine batches of tablets were prepared. The prepared tablets were subjected for pharmacopoeial and non-pharmacopoeial evaluation parameters including loose and tapped bulk density, compressibility index, hausner ratio, angle of repose, friability, hardness, thickness, weight variation, % drug content and in-vitro drug release studies. It can be concluded that the combination of hydrophilic polymers that are retardant in nature are better suited for sustained and controlled drug delivery system than the hydrophilic polymer alone.