Oral In Situ Gel; A Novel Drug Delivery System for Oral Diseases

The conventional dosage forms have the disadvantages like frequent administration, poor bioavailability, unpredictable doses etc. To overcome the problems of the conventional dosage forms, newer research in drug delivery systems directed towards a amalgamation of several technologies, leads to the development of in-situ oral gels, which extend the contact time and slows down the removal of the drug. To improve the bioavailability and to prevent rapid loss of drug, the drug can be formulated as oral in-situ gel using stimuli sensitive polymers. Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. This review work gives information about oral diseases, in situ gel, approaches and polymers used for in situ gelation.