Synthesis, characterization and screening of antimicrobial activity of metal complexes derived from the mannich base, N-(piperidinomethyl)phthalimide

A new Mannich base, N-(Piperidinomethyl)phthalimide (L), formed by the condensation of piperidine, formaldehyde and phthalimide, and its Cu(II) complexes have been synthesized. Their structures have been elucidated on the basis of elemental analysis, molar conductance, IR, UV-visible, mass, 1H NMR and 13C NMR, EPR, magnetic and thermal studies. All the complexes exhibit octahedral geometry. Infrared spectral data show that the organic ligand is bidentate, binding through one of the two carbonyl oxygen atoms of the phthalimide moiety and the piperidine ring nitrogen and also the existence of coordinated water molecules. The X band EPR spectra of Cu(II) complexes in DMSO at room temperature were recorded and their salient features are reported. Thermal data of some of the compounds show that the thermal decompositions take place mostly in two steps to produce metal oxides as final residues. Antimicrobial activities of the newly synthesized compounds were also investigated.