Synthesis of 3,4-Diylidine and N-Substituted Pyrrolidines and its Anti-Microbial Activity

The synthesis of Nitrogen containing heterocycles particularly substituted pyrrolidines constitutes very important moieties of many biologically active molecules1 including natural and non-natural substances. The synthesis of functionalized pyrrolidines continues to attract interest, both for their synthetic challenges,2 and also their value in synthetic chemistry3 and their diverse biological properties.4 The present work includes the synthesis of substituted pyrrolidines from alkyl dihalide and primary amines by simple and efficient cyclocondensation process. This methodology gives varies of substitution pattern on 2,3-position of the pyrrolidines5 Scheme 1. This strategy improved greener synthetic methodology and worked out as a simple and straightforward one-pot approach for the synthesis nitrogen containing heterocycle as pyrrolidines.